Bench: Wet-lab Co-pilot

Bench predicts experimental conditions and generates editable protocols—from expression through stabilization—so you avoid wasted lab cycles. Powered by Astra AI models and agents, it reviews the literature and proposes evidence-backed methods.

Wet-lab work is full of trial and error.

Too much guesswork, too little context. Planning lives in PDFs and memory, so every parameter change restarts the clock and hard-won knowledge doesn’t compound.

Limited Scope

Trial-and-Error Workflows

Choosing host, tag, construct, and buffers is mostly manual. Small nudges force fresh batches and re-optimization, and negative results rarely inform the next run.

Experimental Efforts

Fragmented Know-how

Critical parameters are split across papers, supplementary tables, and lab wikis—making you reinvent screens and miss edge-case constraints buried in the literature.

Missed Insights

Hidden Pitfalls

Incompatible reagents and unrealistic steps slip into drafts and only surface at the bench, burning days and compromising reproducibility and safety.

From Guesswork to Guided Work with Bench

Bench turns your protein sequence into evidence-backed starting points you can run, edit, and iterate—so experimental cycles shorten and learning compounds run-to-run.

AI Predictions

Ready-to-Run

Bench converts sequence + context into editable protocols for expression, purification, crystallization, cryo-EM, and stabilization—with buffers, concentrations, and sensible ranges.

Protein Understanding

Work on Tough Targets

Predict experimental conditions and suggest stabilizing mutations to raise hit rates on unstable or unknown proteins, then iterate toward optimal results.

Discovery

Guardrails for Success

Astra models characterize function, localization, PTMs, and quaternary assembly while agents scan the literature; Bench auto-flags conflicts so errors don’t reach the bench.

FAQ

What is Orbion?

Orbion is an AI-driven platform that helps scientists stabilize, engineer, and purify proteins more efficiently. Orbion identifies the most promising ways to modify proteins (e.g., truncations, mutations) and pinpoints the optimal conditions for structure determination—whether by crystallography or cryo-EM.

How can I use Orbion?

You can upload your protein sequence and any available structural or functional information into the Orbion platform. Orbion will then analyze potential PTMs, functional sites, and instability hotspots, suggest stabilizing modifications, and recommend experimental conditions for purification and structure determination. Think of it as a virtual collaborator, offering insights to guide your lab experiments and streamline your R&D process.

Which proteins can Orbion work with?

Orbion is designed to handle a wide range of proteins, from small soluble enzymes to large multi-domain or membrane-bound complexes. Our models are especially effective for challenging or unstable proteins that are traditionally difficult to crystallize or resolve using cryo-EM.

How does Orbion provide predictions?

Orbion uses neural networks and other machine-learning approaches trained on extensive protein data. Orbion generates scientifically grounded predictions on where and how to modify a protein, as well as which conditions are most likely to yield high-quality structural data.

Is there a free option for academical or public research?

Yes! If you are a researcher in academia or a public institute, and want to use Orbion for your public research studies, you can access Orbion for free. Simply, sign up for our researcher program, and we'll provide you the access very soon.

FAQ

What is Orbion?

Orbion is an AI-driven platform that helps scientists stabilize, engineer, and purify proteins more efficiently. Orbion identifies the most promising ways to modify proteins (e.g., truncations, mutations) and pinpoints the optimal conditions for structure determination—whether by crystallography or cryo-EM.

How can I use Orbion?

You can upload your protein sequence and any available structural or functional information into the Orbion platform. Orbion will then analyze potential PTMs, functional sites, and instability hotspots, suggest stabilizing modifications, and recommend experimental conditions for purification and structure determination. Think of it as a virtual collaborator, offering insights to guide your lab experiments and streamline your R&D process.

Which proteins can Orbion work with?

Orbion is designed to handle a wide range of proteins, from small soluble enzymes to large multi-domain or membrane-bound complexes. Our models are especially effective for challenging or unstable proteins that are traditionally difficult to crystallize or resolve using cryo-EM.

How does Orbion provide predictions?

Orbion uses neural networks and other machine-learning approaches trained on extensive protein data. Orbion generates scientifically grounded predictions on where and how to modify a protein, as well as which conditions are most likely to yield high-quality structural data.

Is there a free option for academical or public research?

Yes! If you are a researcher in academia or a public institute, and want to use Orbion for your public research studies, you can access Orbion for free. Simply, sign up for our researcher program, and we'll provide you the access very soon.

FAQ

What is Orbion?

Orbion is an AI-driven platform that helps scientists stabilize, engineer, and purify proteins more efficiently. Orbion identifies the most promising ways to modify proteins (e.g., truncations, mutations) and pinpoints the optimal conditions for structure determination—whether by crystallography or cryo-EM.

How can I use Orbion?

You can upload your protein sequence and any available structural or functional information into the Orbion platform. Orbion will then analyze potential PTMs, functional sites, and instability hotspots, suggest stabilizing modifications, and recommend experimental conditions for purification and structure determination. Think of it as a virtual collaborator, offering insights to guide your lab experiments and streamline your R&D process.

Which proteins can Orbion work with?

Orbion is designed to handle a wide range of proteins, from small soluble enzymes to large multi-domain or membrane-bound complexes. Our models are especially effective for challenging or unstable proteins that are traditionally difficult to crystallize or resolve using cryo-EM.

How does Orbion provide predictions?

Orbion uses neural networks and other machine-learning approaches trained on extensive protein data. Orbion generates scientifically grounded predictions on where and how to modify a protein, as well as which conditions are most likely to yield high-quality structural data.

Is there a free option for academical or public research?

Yes! If you are a researcher in academia or a public institute, and want to use Orbion for your public research studies, you can access Orbion for free. Simply, sign up for our researcher program, and we'll provide you the access very soon.