The Astra Suite

One Sequence In. The Whole Protein Out.

Astra is Orbion's family of protein AI models. Each reads a sequence and returns a different layer of understanding — structure confidence, function, modifications, binding, topology, and stability. Together, they power the platform.

StructureFunctionModificationsBindingTopologyStability

The Models

Nine Reads on Every Protein

Seven models, each trained for one job and evaluated on public baselines. Several are documented in open preprints; explore any of them below.

Preprint

AstraPTM2

Modifications

Flags where 39 types of post-translational modification are likely — phosphorylation, glycosylation, ubiquitination and more — at single-residue resolution.

39 PTM TypesPer-Residue

Preprint

AstraROLE2 & AstraSUIT2

Function & Suitability

A ten-factor profile: what a protein does (EC, GO, pathways) and how to work with it (cofactors, domains, host, membrane type, localization) — even for de-novo proteins.

FunctionSuitability

Preprint

AstraBIND

Binding

Locates ligand-binding residues and retrieves likely ligands from a 2M+ panel across 17 categories — combining sequence, structure, and homology.

Binding ResiduesLigand Types

AstraUNFOLD

Topology & Disorder

Membrane topology, intrinsic disorder, and amyloid-aggregation propensity — read residue by residue, from sequence alone.

TopologyDisorderAggregation

AstraDTM & AstraDDG

Stability

How a single mutation shifts melting temperature (ΔTm) and folding free energy (ΔΔG) — so you can rank the changes most likely to stabilize a target.

ΔTm (°C)ΔΔG (kcal/mol)

…and more in the platform

Structure confidence (pLDDT), expression yield, and construct design models power the rest of Orbion.

Explore the Platform

One System

Built to Work Together

The models aren't siloed endpoints. Inside the Orbion platform they run in sequence — characterize a protein top to bottom, then score the mutations and constructs worth making — so a single upload turns into a decision.

See the Platform

Pipeline

Characterize

Structure, PTMs, Function, Binding, Topology

Stabilize

Rank Mutations by ΔTm / ΔΔG

Design

Score Constructs for Expression Yield

Decide

The Handful Worth Taking to the Bench

Put Astra on Your Targets

Every Astra model runs inside the Orbion platform. Bring a sequence and get the full read-out — structure, function, modifications, binding, and stability.

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