Illustration of a Protein Looking Deep on Another Protein with a Magnifying Glass

UniProt for Novel Proteins

Orbion empowers you to upload any novel protein sequence and instantly access detailed structural, physicochemical, and functional insights, and generate experimental protocols. Explore similar proteins, visualize sequence features, and gain experimental protocols for more effective protein research.

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Bench:

Wet-lab Co-pilot

Predicts experimental conditions and generates editable protocols.

Details

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Characterize:

Protein Intelligence Engine

Maps the hidden logic of your protein, revealing hows.

Details

Orbion Platform's Overview Page on Green Fluorescent Protein

UniProt and PDB are only for known proteins.

We rely on UniProt and PDB every day to understand well‐characterized proteins, but what if you’re working on something entirely new—an uncharacterized protein or a de novo design? Traditional databases often can’t help.

Limited Scope

UniProt and PDB only cover known proteins. If your sequence has no close homology or entry, you’re on your own.

Illustration Representing Experimental Efforts

Experimental Efforts

Without reference data, researchers rely on trial and error. Predicting post‐translational modifications or binding sites often means lengthy, costly lab work.

Illustration Representing Missed Insights

Missed Insights

Even with partial homology, deeper properties stay hidden. Stability, flexible loops, and PTMs remain uncertain until you spend weeks in the lab.

Introducing The Fastest Way to Explore Any Protein

Orbion lets you upload any protein—known or novel—and immediately generates a comprehensive set of structural and functional insights. It’s the UniProt for every protein, even if it’s never been characterized before.

Illustration Representing AI-Driven Predictions

AI-Driven Predictions

Orbion processes any protein sequence with advanced computational models to predict features, suitability, structure, PTMs, binding pockets, and more.

Illustration Representing Deeper Protein Understanding

Deeper Protein Understanding

Go beyond the basics: see potential PTMs, stability indexes, flexible regions, and functional motifs—all in one place.

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Accelerated Discovery

Stop guessing. Orbion’s in-silico insights and protocol suggestions let you streamline experimental design, reducing lab work from weeks to days.

How Platform Works

The platform is straightforward: simply enter your protein sequence to gain in‐depth insights within minutes.

Illustration Representing Orbion Platform's First Step on Protein Analysis - Sequence Entry

Enter Sequence

Paste your amino acid sequence—no special formatting required.

Illustration Representing Orbion Platform's Second Step on Protein Analysis - Property Review

Review Properties

Orbion’s AI analyzes your sequence to predict physicochemical and stability properties, identify similar proteins, propose 3D structures, and highlight potential PTMs or binding sites.

Illustration Representing Orbion Platform's Third Step on Protein Analysis - Experiment Guidance

Guide Experiments

Use Orbion’s suggested protocols and stable constructs to fine‐tune your experimental strategy—whether you’re planning, setting up crystallization, exploring cryo‐EM, or planning site‐directed mutagenesis.

FAQ

What is Orbion?

Orbion is an AI-driven platform that helps scientists stabilize, engineer, and purify proteins more efficiently. Orbion identifies the most promising ways to modify proteins (e.g., truncations, mutations) and pinpoints the optimal conditions for structure determination—whether by crystallography or cryo-EM.

How can I use Orbion?

You can upload your protein sequence and any available structural or functional information into the Orbion platform. Orbion will then analyze potential PTMs, functional sites, and instability hotspots, suggest stabilizing modifications, and recommend experimental conditions for purification and structure determination. Think of it as a virtual collaborator, offering insights to guide your lab experiments and streamline your R&D process.

Which proteins can Orbion work with?

Orbion is designed to handle a wide range of proteins, from small soluble enzymes to large multi-domain or membrane-bound complexes. Our models are especially effective for challenging or unstable proteins that are traditionally difficult to crystallize or resolve using cryo-EM.

How does Orbion provide predictions?

Orbion uses neural networks and other machine-learning approaches trained on extensive protein data. Orbion generates scientifically grounded predictions on where and how to modify a protein, as well as which conditions are most likely to yield high-quality structural data.

Is there a free option for academical or public research?

Yes! If you are a researcher in academia or a public institute, and want to use Orbion for your public research studies, you can access Orbion for free. Simply, sign up for our researcher program, and we'll provide you the access very soon.