Characterize
Everything a Sequence Can Tell You
Paste a sequence and get the full read on a protein — structure and confidence, modifications, binding pockets, membrane topology, and disorder — before you order a single primer.
One Pass, the Whole Picture
Structure models stop at the fold. Characterize combines structure with the annotations that decide whether a protein is workable — modifications, binding sites, topology, and disorder — in a single run, on any protein family.
See It on a Real Protein
Rhodopsin, Fully Annotated
A per-residue read-out: pLDDT confidence, PTM marks, binding sites, and membrane topology — all aligned to the sequence and mapped onto the structure.
What You Get
Six Reads, One Run
Each output is produced by an open, benchmarked Astra model. Follow any of them to the science behind the prediction.
Structure & Confidence
A predicted 3D fold with per-residue pLDDT, so you know which regions to trust.
In Detail
Every Annotation Characterize Returns
The full surface area of one run, per residue and across the whole sequence — so you can judge the fit before you talk to us.
Structure Prediction
- AlphaFold2
- Boltz-2
- ESMFold
- Predicted 3D Structure from Sequence Alone
- 2D Grid, 3D, Track, and Schematic Views
Structure & Confidence
- Per-Residue pLDDT Confidence, Colour-Coded
- Confidence Bands Across the Whole Chain
- Low-Confidence Regions Flagged, Not Hidden
- Mean pLDDT and Disorder Rate at a Glance
Post-Translational Modifications
- Phosphorylation Sites
- Disulfide Bonds
- Acetylation and Ubiquitination
- Oxidation
- 39 Modification Types in Total
Binding Sites & Cofactors
- Ligand-Binding Residues, Position by Position
- Small-Molecule Pockets, Grouped and Ranked
- Metal Cofactors — Magnesium, Zinc, Nickel, Cobalt
- Cross-Links Out to the Reference Databases
Membrane Topology
- Transmembrane Helices and Span Count
- Extramembrane Regions
- Inside / Outside Orientation
- Ambiguous Stretches Called Out Explicitly
Disorder & Aggregation
- Intrinsically Disordered Regions
- Amyloid-Aggregation Propensity
- Read per Residue Along the Full Sequence
- Aggregation-Prone Stretches Flagged Early
Function & Suitability
- EC Number and GO Terms
- Pathways and Protein Categories
- Cofactors, Domains, and Host Lineage
- Subcellular Localization
Every annotation is exportable per residue. Exploratory Mode surfaces lower-confidence calls rather than suppressing them.
Characterize Your Target
Bring a sequence and get the full read-out in one pass — structure, modifications, binding, topology, and disorder. No wet lab required to know where to look first.