Blog
SDS-PAGE Band at the Wrong Molecular Weight
Why Does My Protein Lose Activity After Freezing
My His-Tagged Protein Doesn't Bind Ni-NTA
The Same Sequence Signal Can Mean Opposite Things
Why Some Binder Signals Transfer and Others Flip
Can Quantum Computing Actually Improve Protein-Ligand Binding Prediction?
Why Your Thermal Shift Assay Doesn't Predict Real Stability
Beyond Structure and Affinity: Our New Preprint on CD20 and EGFR Benchmarks
Why Your Protein Works in the Assay but Fails in Cells
Homology Modeling in the AlphaFold Era: What Still Matters
Codon Optimization Doesn't Fix Everything
Can the current tools predict protein epistasis?
Why Your Protein Precipitates During Buffer Exchange
Protein Language Models Explained for Bench Scientists
Intrinsically Disordered Regions: Why They Break Your Protein Pipeline
MBP vs SUMO vs GST vs Thioredoxin: Choosing the Right Fusion Partner
From Single Mutants to Combinatorial Libraries: Scaling Protein Engineering
What pLDDT and PAE Actually Tell You (And What They Don't)
When to Give Up on a Protein Target
The Batch-to-Batch Variability Problem in Protein Production
Why High-Throughput Screening Hits Don't Reproduce
Your Protein Is a Dimer in Solution But a Monomer in the Crystal
The Tag Removal Problem: Why Your Protease Won't Cleave
Why Your Protein Loses Activity After Purification (Even Though It's Pure)
From Structure to Experiment: What Computational Biologists Miss
Why Stabilizing Mutations Sometimes Make Everything Worse
Finding Druggable Pockets When the Active Site Is Too Conserved
The Hidden Link Between Disorder, Aggregation, and Failed Purifications
How to Interpret AlphaFold Confidence Scores for Multi-Chain Complexes
Why Your Protein Doesn't Express in E. coli (When It Should)
Modern Alternatives to FoldX and Rosetta: The AI/ML Revolution
FoldX and Rosetta: The 5 Reasons They're Still Your Bottleneck
How to Design Optimal Construct Boundaries: Step-by-Step Workflow
Construct Boundary Design: The 4 Problems Killing Your Protein Expression
Fixing Cryo-EM Sample Problems: Optimization Strategies & Workflows
The 5 Cryo-EM Sample Killers: Understanding Why Your Particles Won't Align
How to Fix Crystallization Problems: The Modern Troubleshooting Guide
Why Your Protein Won't Crystallize: Understanding the 6 Common Failure Modes
Detergent-Free Membrane Protein Purification: Nanodiscs and Beyond
Cofactor Prediction and Supplementation: A Practical Guide
How to Engineer Developable Antibodies: AI-Driven Optimization
Membrane Protein Purification: Detergent Screening Guide
Why Your Protein Aggregates (It's Missing Zinc)
#ProteinWrapped: Your Protein of the Year
The Antibody Developability Crisis: Why 40% of Candidates Fail
Why Your Protein Aggregates (And How to Fix It): A Structural Biologist's Guide
The Art of "Domesticating" Proteins: A Guide to GPCR Construct Design
Structure-Based Drug Design: From Protein Structure to Lead Compound
Complex Predictions Now Live — Structure to Protocol in One Workflow
AlphaFold's Limitations: What It Can't Predict (And How to Fill the Gaps)
How to Choose Expression Systems for Your Protein's PTM Requirements
GPCRs: Bridging the Gap in the Druggable Genome
AstraBIND Preprint is Published on bioRxiv
Orbion Wins Drumbeat Capital Award at Stage Two 2025
Orbion at leadXpro’s 10-Year Symposium
AstraPTM2 Preprint is Published on bioRxiv
Characterize is Live!
Orbion was in Berlin Bio Innovation Day
450+ Protocols in August
Model Update — AstraROLE2 + AstraSUIT2
Bench, Your Wet-lab Co-pilot, Now in Early Access
Advancing Structural Biology with leadXpro
Supporting Oncology Research at Columbia University and CUNY
Astra AI demo is live! Annotate your proteins and find protocols.
New Preprint — AstraROLE + AstraSUIT for Full-Length Protein Annotation
Orbion Announces Application for ESA BSGN/MEDES Accelerator
Orbion Showcases at WHU Accelerator Demo Day
Orbion Hits the Google Stage with Antler
Aniruddh Goteti at WHU Entrepreneurship Roundtable Podcast
Orbion on Stage at BIONNALE 2025
Orbion Beta is now live!
