AstraINTERACTION
Does It Bind? Interaction Triage From Sequence
Folding a complex tells you a shape, not whether two partners actually interact. AstraINTERACTION scores the interaction directly from sequence — peptide and MHC, receptor and G-protein, kinase and substrate, and protein pairs — as a fast, confidence-gated pre-filter before you commit to structure prediction or the bench.
Immunopeptidomics-Grade on Peptide–MHC
On held-out peptide–MHC presentation, AstraINTERACTION reaches specialist accuracy — the read that matters for antigen presentation and immunogenicity triage — and extends the same engine across a family of interaction types.
Real Structure · Rhodopsin (Class-A GPCR)
Which transducer a receptor couples
What It Scores
One Engine, Many Interaction Types
Each interaction type is evaluated on a hard split — no sequence-similarity leakage between train and test — so the numbers reflect novel pairs, not memorized ones.
AUROC on protein-disjoint / declustered splits. Local-motif interactions (peptide–MHC, kinase site) score highest; whole-protein pairs are coarser but still useful as a pre-filter.
How to Read It
A Confidence-Gated Pre-Filter
Cheap-Score Many Pairs
Screen a large set of candidate interactions from sequence before spending compute on folding or a wet-lab assay.
Keep the Survivors
Use it as a triage layer — carry the high-confidence interactions forward, drop the rest, and narrow the panel early.
It Abstains
The engine reports its own confidence and holds back when the signal is weak, rather than forcing a call it can't stand behind.
Antibody–antigen interface prediction runs through a structure-based cascade and is offered as confidence-gated, exploratory triage — surfaced only where the interface confidence is high, and flagged as predicted-and-unverified everywhere else. We report it as a research capability, not a mapped epitope.
Performance
Matches Specialists, Unified in One Engine
The value is one interaction engine that spans presentation, coupling, and enzyme–substrate reads — each evaluated honestly on hard splits — rather than a separate tool per interaction type.
Put Astra on Your Targets
Every Astra model runs inside the Orbion platform. Bring a sequence and get the full read-out — structure, function, modifications, binding, and stability.