Why do protein experiments fail?
Sometimes the protein is not soluble. Sometimes it is not stable. Sometimes the construct is simply wrong for the experiment.
Tags, fusion partners, solubility partners, signal peptides, and truncations can all help. But deciding which ones to use — and in which combination — is still often an expensive, trial-and-error-driven, and frustrating process.
That is exactly why we built Design.
Design is a new Orbion module that helps teams generate, compare, and prioritize protein constructs before moving into cloning and wet-lab work.
With Design, you can:
- create hundreds of combinatorial constructs using different components
- evaluate key in-silico metrics (solubility, disorder, aggregation, and thermostability), scored and ranked automatically, so you can shortlist before touching a pipette
- generate construct ideas with AI
- see the assembled protein sequence and codon-optimized DNA directly, without the copy-paste burden
In short, Design is a decision-making layer for construct selection. It is built to reduce failed experimental starts and make construct design more systematic — before committing weeks of cloning and expression screening.
If your team works on recombinant protein expression, structural biology, or difficult protein targets, this one is especially relevant.
Have a target in mind? Open your dashboard and run the Design workflow on your own protein.
